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Duane Hinton

Lecturer
Biology
College of Arts & Sciences
Contact
1700 SW College Ave
Topeka, KS 66621-1117
785.670.2165
Degrees & Certifications
Washburn University, Bachelor of Arts
Univ of Kansas Medical Ctr, Doctor of Philosophy
Teaching
  • BI 100 J, Intro to Biology
  • BI 275 A, Human Anatomy
  • BI 275 AL1, Human Anatomy
  • BI 275 AL2, Human Anatomy
  • BI 275 B, Human Anatomy
  • BI 275 BL1, Human Anatomy
  • BI 275 BL2, Human Anatomy
  • BI 357 A, Histology
  • BI 357 AA, Histology
  • BI 390 B, Biology Seminar
  • BI 395 F, Research In Biology
Scholarly Interests/Activities

Development of the vertebrate limb is a complex example of pattern formation requiring cellular proliferation, differentiation, apoptosis and tissue rearrangement.  The extensive tissue remodeling required to produce functional digits utilizes a multitude of enzymes and growth factors to eliminate both cells and extracellular matrix (ECM). Specifically, we are interested in understanding how the ECM is degraded during digitation of the developing limb.  Matrix metalloproteinases (MMPs) are a family of structurally related, zinc-containing enzymes that degrade various components of the extracellular matrix.  Recent studies indicated that MMP-2 plays a pro-apoptotic role in several systems.  We are interested in the potential role MMP-2 might play during limb formation in the chick.  We hypothesize that matrix breakdown precedes and may, in fact, initiate programmed cell death during digitation.  In order to test this hypothesis, we are examining the effects of knocking down the expression of MMP-2 enzyme activity by using inhibitory Morpholino antisense oligos.

Service Interests/Activities

President of the Kansas Academy of Science, 2012